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In mouse models deficient in the Abca4 and Rdh8 genes, a deficiency in the clearance of photoreceptor outer segment discs, thinning of the retinal photoreceptor layer postlight exposure, the accumulation of atRAL in the retina, diminished GSH levels, aberrant expression of the lipid metabolism-related proteins COX2 and ACSLA, and heightened lipid peroxidation—indicators of ferroptosis—are observed (187)

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